<p>False-Negative Serum Cryptococcal Antigen Lateral Flow Immunoassay Result for a Patient with Disseminated Cryptococcal Disease</p>
نویسندگان
چکیده
منابع مشابه
Disseminated cryptococcal infection despite treatment for cryptococcal meningitis.
Case Reports (Dr R F Miller) Case 1 A 25 year old Caucasian heterosexual man was found to be HIV I antibody positive in July 1989, when he presented to another hospital with cryptococcal meningitis. At this time his CD4+ count was 190 (normal range = 350-2,200)/mm3. Investigations showed normal urea and electrolyte levels and liver function tests; CT of the head was normal. Blood and urine cult...
متن کاملPoint-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid.
The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R(2) = 0.7) and predicted 2- and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.
متن کاملSerum cross-reactivity with Aspergillus galactomannan and cryptococcal antigen during fatal disseminated Trichosporon dermatis infection.
To the Editor—We thank Dr. Dylewski [1] for the feedback on our article [2]. It is understood that the usefulness of nucleic acid amplification (NAA) tests varies with the prevalence of the disease among the population being tested. In our article, we do not advocate NAA testing for all specimens submitted for culture. For patients whose specimens have negative acid–fast bacilli (AFB) smear res...
متن کاملEvaluation of a New Cryptococcal Antigen Lateral Flow Immunoassay in Serum, Cerebrospinal Fluid and Urine for the Diagnosis of Cryptococcosis: A Meta-Analysis and Systematic Review
BACKGROUND A new lateral flow immunoassay (LFA) for the detection of cryptococcal antigen was developed. OBJECTIVE We aimed to systematically review all relevant studies to evaluate the diagnostic accuracy of the cryptococcal antigen LFA on serum, CSF and urine specimens. METHODS We searched public databases including PubMed, Web of Science, Elsevier Science Direct and Cochrane Library for ...
متن کاملEvaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia
A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed h...
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ژورنال
عنوان ژورنال: Infection and Drug Resistance
سال: 2020
ISSN: 1178-6973
DOI: 10.2147/idr.s265784